The duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress.

In general, the recommended total daily dosage is 12 g of piperacillin/1.5 g of tazobactam given in divided doses every 8 hours. The total daily dose depends on the severity and localization of the infection and can vary from 2.25 g to 4.5 g of piperacillin/tazobactam administration every 6 or 8 hours.

For bacterial infections in neutropenic patients, the recommended dose is 4 g piperacillin/0.5 g tazobactam administered every 6 hours in combination with an aminoglycoside.

For neutropenic children with fever suspected to be due to bacterial infections,* the recommended dose is 80 mg piperacillin/10 mg tazobactam per kg body weight, administered every 6 hours (in combination with an aminoglycoside).

For children weighing over 50 kg, follow the adult dosing, in combination with the appropriate dose of an aminoglycoside.

* Not to exceed the maximum 4 g/0.5 g per dose over 30 minutes.

The intravenous dose should be adjusted to the degree of actual renal impairment as follows (each patient must be monitored closely for signs of substance toxicity; medicinal product dose and interval should be adjusted accordingly):

In adults and children 12 years and older with creatinine clearances:^†

• >40 ml/min, no dose adjustment is necessary
• 20–40 ml/min, the maximum dose suggested is 4 g/0.5 g every 8 hours
• <20 ml/min, the maximum dose suggested is 4 g/0.5 g every 12 hours

In children 2–12 years of age with creatinine clearances:^‡

• >50 ml/min, no dose adjustment is necessary
• ≤50 ml/min, the suggested dose is 70 mg piperacillin/8.75 mg tazobactam/kg every 8 hours

No dose adjustment is necessary.

Patients over 65 years are not at an increased risk of developing adverse effects solely because of age. However, dosage should be adjusted in the presence of renal insufficiency.